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A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice.

Abstract:

Gene-targeted mice lacking the AMPA receptor subunit glutamate receptor-A (GluRA) (GluR1) and wild-type controls were compared on a radial-maze task in which the same three of six arms were always baited, but in which the rewards of milk were not replaced within a trial. This procedure allowed not only a within-subjects but also a within-trials assessment of both spatial working memory (WM) and reference memory (RM) in GluRA-/- mice, using identical spatial cues. In experiment 1, the GluRA-/-...

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Authors


Schmitt, WB More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Seeburg, PH More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
23
Issue:
9
Pages:
3953-3959
Publication date:
2003-05-05
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:ae045946-7afd-41fe-ba32-401295e156d4
Source identifiers:
18805
Local pid:
pubs:18805

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