Journal article icon

Journal article

CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts.

Abstract:

CCN2 is induced by transforming growth factor-beta (TGFbeta) in fibroblasts and is overexpressed in connective tissue disease. CCN2 has been proposed to be a downstream mediator of TGFbeta action in fibroblasts; however, the role of CCN2 in regulating this process unclear. By using embryonic fibroblasts isolated from ccn2-/- mice, we showed that CCN2 is required for a subset of responses to TGFbeta. Affymetrix genome-wide expression profiling revealed that 942 transcripts were induced by TGFb...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1074/jbc.m511343200

Authors


Shi-wen, X More by this author
Stanton, LA More by this author
Kennedy, L More by this author
Expand authors...
Journal:
The Journal of biological chemistry
Volume:
281
Issue:
16
Pages:
10715-10726
Publication date:
2006-04-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:adf0f577-f8c5-4dbe-a287-1c3f9b11d4e1
Source identifiers:
223506
Local pid:
pubs:223506

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP