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Extracellular vesicles released following heat stress induce bystander effect in unstressed populations

Abstract:

Cells naïve to stress can display the effects of stress, such as DNA damage and apoptosis, when they are exposed to signals from stressed cells; this phenomenon is known as the bystander effect. We previously showed that bystander effect induced by ionising radiation are mediated by extracellular vesicles (EVs). Bystander effect can also be induced by other types of stress, including heat shock, but it is unclear whether EVs are involved. Here we show that EVs released from heat shocked cells...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1080/20013078.2017.1340746

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, RDM Cardiovascular Medicine
Role:
Author
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Cancer and Polio Research Fund (GB) More from this funder
Oxford Brookes University More from this funder
Publisher:
Taylor and Francis Open Publisher's website
Journal:
Journal of Extracellular Vesicles Journal website
Volume:
6
Issue:
1
Pages:
1340746
Publication date:
2017-07-03
Acceptance date:
2017-06-05
DOI:
EISSN:
2001-3078
ISSN:
2001-3078
Pubs id:
pubs:724885
URN:
uri:ade60050-8852-4eba-9fd6-5b204eda072d
UUID:
uuid:ade60050-8852-4eba-9fd6-5b204eda072d
Local pid:
pubs:724885
Paper number:
1

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