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TRPing the switch on pain: an introduction to the chemistry and biology of capsaicin and TRPV1.

Abstract:

Capsaicin has elicited great interest for many centuries due to its noticeable culinary and medical properties. The discovery of its receptor, TRPV1, sparked an explosion of interest in TRPV1 and the development of TRPV1 agonists and antagonists. This tutorial review provides an introduction to the history of both capsaicin and TRPV1. Two TRPV1 antagonists that are undergoing clinical trials are highlighted, as are some light-activated molecular tools that are enabling the intracellular study...

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Publication status:
Published

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Publisher copy:
10.1039/b610226n

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Chemical Society reviews
Volume:
37
Issue:
8
Pages:
1530-1545
Publication date:
2008-08-01
DOI:
EISSN:
1460-4744
ISSN:
0306-0012
Source identifiers:
52016
Language:
English
Keywords:
Pubs id:
pubs:52016
UUID:
uuid:add423ee-cbfa-414f-bf80-a0d283c93707
Local pid:
pubs:52016
Deposit date:
2012-12-19

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