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The impact of cardiac radiation dosimetry on survival following radiotherapy for non-small cell lung cancer

Abstract:

Purpose
The heart receives high radiation doses during radiotherapy of advanced-stage lung cancer. We have explored associations between overall survival, cardiac radiation doses and electrocardiographic (ECG) changes in patients treated in IDEAL-CRT, a trial of isotoxically-escalated concurrent chemoradiation delivering tumor doses of 63-73Gy.

Patients and Methods
Dosimetric and survival data were analyzed for 78 patients. The whole heart, pericardium, AV node, and wal...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.ijrobp.2017.04.026

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Landau, DB More by this author
Counsell, N More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, CRUK/MRC Ox Inst for Radiation Oncology
Khwanda, A More by this author
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Cancer Research UK More from this funder
Publisher:
Elsevier Publisher's website
Journal:
International Journal of Radiation Oncology - Biology - Physics Journal website
Volume:
99
Issue:
1
Pages:
51-60
Publication date:
2017-04-27
Acceptance date:
2017-04-19
DOI:
EISSN:
1879-355X
ISSN:
0360-3016
Pubs id:
pubs:698179
URN:
uri:add2a30d-3f59-4ff8-a108-85571f6bab98
UUID:
uuid:add2a30d-3f59-4ff8-a108-85571f6bab98
Local pid:
pubs:698179

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