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The organization of replication and transcription.

Abstract:

Models for replication and transcription often display polymerases that track like locomotives along their DNA templates. However, recent evidence supports an alternative model in which DNA and RNA polymerases are immobilized by attachment to larger structures, where they reel in their templates and extrude newly made nucleic acids. These polymerases do not act independently; they are concentrated in discrete "factories," where they work together on many different templates. Evidence for mode...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Science (New York, N.Y.) More from this journal
Volume:
284
Issue:
5421
Pages:
1790-1795
Publication date:
1999-06-01
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Keywords:
Pubs id:
pubs:18169
UUID:
uuid:adc5f85b-fb4d-45d0-b810-97b7f637b266
Local pid:
pubs:18169
Source identifiers:
18169
Deposit date:
2012-12-19

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