Journal article
Reduced dosage of ERF causes complex craniosynostosis in humans and mice and links ERK1/2 signaling to regulation of osteogenesis.
- Abstract:
-
The extracellular signal-related kinases 1 and 2 (ERK1/2) are key proteins mediating mitogen-activated protein kinase signaling downstream of RAS: phosphorylation of ERK1/2 leads to nuclear uptake and modulation of multiple targets. Here, we show that reduced dosage of ERF, which encodes an inhibitory ETS transcription factor directly bound by ERK1/2 (refs. 2,3,4,5,6,7), causes complex craniosynostosis (premature fusion of the cranial sutures) in humans and mice. Features of this newly recogn...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/ng.2539
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Authors
Bibliographic Details
- Journal:
- Nature genetics
- Volume:
- 45
- Issue:
- 3
- Pages:
- 308-313
- Publication date:
- 2013-03-01
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- Source identifiers:
-
375699
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:375699
- UUID:
-
uuid:adc5ca06-c2b0-4ade-aec3-636f2daca465
- Local pid:
- pubs:375699
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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