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Journal article

The chemical biology of human metallo-β-lactamase fold proteins.

Abstract:

The αββα metallo β-lactamase (MBL) fold (MBLf) was first observed in bacterial enzymes that catalyze the hydrolysis of almost all β-lactam antibiotics, but is now known to be widely distributed. The MBL core protein fold is present in human enzymes with diverse biological roles, including cell detoxification pathways and enabling resistance to clinically important anticancer medicines. Human (h)MBLf enzymes can bind metals, including zinc and iron ions, and catalyze a range of chemically inte...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tibs.2015.12.007

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Cancer Research UK More from this funder
Biotechnology and Biological Sciences Research Council More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Trends in Biochemical Sciences Journal website
Volume:
41
Issue:
4
Pages:
338-355
Publication date:
2016-01-21
DOI:
EISSN:
0968-0004
ISSN:
0968-0004
Source identifiers:
597829
Language:
English
Keywords:
Pubs id:
pubs:597829
UUID:
uuid:adc4dcac-6cd4-4319-96a5-9bc5a36f2381
Local pid:
pubs:597829
Deposit date:
2016-02-18

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