The chemical biology of human metallo-β-lactamase fold proteins.
The αββα metallo β-lactamase (MBL) fold (MBLf) was first observed in bacterial enzymes that catalyze the hydrolysis of almost all β-lactam antibiotics, but is now known to be widely distributed. The MBL core protein fold is present in human enzymes with diverse biological roles, including cell detoxification pathways and enabling resistance to clinically important anticancer medicines. Human (h)MBLf enzymes can bind metals, including zinc and iron ions, and catalyze a range of chemically inte...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
(Version of record, pdf, 3.4MB)
- Publisher copy:
- Copyright holder:
- Pettinati et al
- Copyright date:
- Copyright © 2016 The Authors. Published by Elsevier Ltd. Open Access funded by Medical Research Council. Under a Creative Commons license.
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record