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Journal article

Cytotoxic T-cell activity antagonized by naturally occurring HIV-1 Gag variants.

Abstract:

Most asymptomatic individuals infected with HIV-1 have a cytotoxic T lymphocyte (CTL) response to the virus Gag proteins which can be demonstrated in vitro. Epitopes have been mapped in p17 Gag and p24 Gag restricted by HLA-B8 (p17-3 and p24-13) and -B27 (p24-14). Viruses isolated from patients who make CTL responses to these peptides vary within the genetic sequences encoding these epitopes and some mutations lead to reduction in killing activity in vitro. This was attributed to either failu...

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Publication status:
Published

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Publisher copy:
10.1038/369403a0

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division, Biomedical Research Centre
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
More by this author
Institution:
University of Oxford
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Journal:
Nature
Volume:
369
Issue:
6479
Pages:
403-407
Publication date:
1994-06-05
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:adbc81b3-487a-433c-8252-9234d30fd70f
Source identifiers:
29692
Local pid:
pubs:29692

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