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Endohexosaminidase M: exploring and exploiting enzyme substrate specificity.

Abstract:
Oxazoline saccharides have been synthesised and tested as glycosyl donors for endohexosaminidase M (Endo M)-catalysed glycosylation of a GlcNAcAsn glycosyl amino acid. Endo M-catalysed glycosylation is not limited to donors containing the Manβ(1-4)GlcNAc linkage, and replacement of the core mannose unit by glucose promotes irreversible glycosylation. In this case, use of a modified oxazoline donor as a transition-state mimic allows enzyme-catalysed synthesis, but precludes product hydrolysis. © 2006 Wiley-VCH Verlag GmbH and Co. KGaA.
Publication status:
Published

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Publisher copy:
10.1002/cbic.200600183
Journal:
Chembiochem : a European journal of chemical biology More from this journal
Volume:
7
Issue:
8
Pages:
1177-1180
Publication date:
2006-08-01
DOI:
EISSN:
1439-7633
ISSN:
1439-4227
Language:
English
Keywords:
Pubs id:
pubs:117884
UUID:
uuid:adbb20b5-4195-4fab-bfac-84463147b9f7
Local pid:
pubs:117884
Source identifiers:
117884
Deposit date:
2012-12-19

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