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Journal article

Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.

Abstract:

Cutaneous squamous cell carcinomas (cSCCs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cSCC tumorigenesis remain poorly defined. We have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 cSCCs using paired non-tumor samples. The most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, ...

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Publisher copy:
10.1038/jid.2008.408

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Journal:
The Journal of investigative dermatology
Volume:
129
Issue:
6
Pages:
1562-1568
Publication date:
2009-06-05
DOI:
EISSN:
1523-1747
ISSN:
0022-202X
URN:
uuid:adb753a7-a2c8-4fba-a906-6ee9f106f3c7
Source identifiers:
295173
Local pid:
pubs:295173

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