- Abstract:
-
Cutaneous squamous cell carcinomas (cSCCs) are the second most frequent cancers in fair-skinned populations; yet, because of their genetic heterogeneity, the key molecular events in cSCC tumorigenesis remain poorly defined. We have used single nucleotide polymorphism microarray analysis to examine genome-wide allelic imbalance in 60 cSCCs using paired non-tumor samples. The most frequent recurrent aberrations were loss of heterozygosity at 3p and 9p, observed in 39 (65%) and 45 (75%) tumors, ...
Expand abstract - Publisher copy:
- 10.1038/jid.2008.408
-
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- Journal:
- The Journal of investigative dermatology
- Volume:
- 129
- Issue:
- 6
- Pages:
- 1562-1568
- Publication date:
- 2009-06-05
- DOI:
- EISSN:
-
1523-1747
- ISSN:
-
0022-202X
- URN:
-
uuid:adb753a7-a2c8-4fba-a906-6ee9f106f3c7
- Source identifiers:
-
295173
- Local pid:
- pubs:295173
- Language:
- English
- Keywords:
- Copyright date:
- 2009
Journal article
Single nucleotide polymorphism array analysis defines a specific genetic fingerprint for well-differentiated cutaneous SCCs.
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