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The distribution of IgG subclasses in the lupus band suggests disease-specific alteration in subclass switching rather than polyclonal B-cell activation.

Abstract:

Deposition of immunoglobulins in the skin of patients with lupus erythematosus (LE), demonstrable as a linear band 'lupus band' at the basement membrane zone (BMZ) by direct immunofluorescence, was first described in 1963. Four decades after the discovery of the lupus band, a basic question regarding the origin of immunoglobulins of the lupus band is still unanswered. Is the lupus band just a manifestation of polyclonal B-cell activation commonly seen in systemic LE (SLE)? The distribution of...

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Publication status:
Published

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Authors


Alahlafi, AM More by this author
Wordsworth, P More by this author
Wojnarowska, F More by this author
Journal:
Clinical and experimental dermatology
Volume:
29
Issue:
3
Pages:
288-292
Publication date:
2004-05-05
DOI:
EISSN:
1365-2230
ISSN:
0307-6938
URN:
uuid:adb0714f-19c6-4b2f-a982-1cceb951b988
Source identifiers:
24553
Local pid:
pubs:24553

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