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Journal article

Cytomegalovirus e127 protein interacts with the inhibitory CD200 receptor.

Abstract:
CD200 is a cell surface glycoprotein that binds an inhibitory receptor (CD200R) on myeloid cells. CD200 orthologues are present in many species of virus, and we show that the rat cytomegalovirus CD200 orthologue (e127) is expressed at the cell surface on infected cells. It binds the host CD200R with the same affinity as that of the host protein, and thus this protein acts as a close mimic of the host protein and has the potential to downregulate immune responses to the virus.
Publication status:
Published

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Publisher copy:
10.1128/jvi.00064-11

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Author
Journal:
Journal of virology More from this journal
Volume:
85
Issue:
12
Pages:
6055-6059
Publication date:
2011-06-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:130888
UUID:
uuid:adae164d-e202-4195-92a9-6ebc45e26c08
Local pid:
pubs:130888
Source identifiers:
130888
Deposit date:
2012-12-19

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