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Journal article

Whole-genome sequencing identifies homozygous BRCA2 deletion guiding treatment in dedifferentiated prostate cancer

Abstract:

Whole-genome sequencing (WGS) has transformed the understanding of the genetic drivers of cancer and is increasingly being used in cancer medicine to identify personalized therapies. Here we describe a case in which the application of WGS identified a tumoral BRCA2 deletion in a patient with aggressive dedifferentiated prostate cancer that was repeat-biopsied after disease progression. This would not have been detected by standard BRCA testing, and it led to additional treatment with a mainte...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1101/mcs.a001362

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Fairfax, B
Grant:
Intermediate Clinical Fellow (201488/Z/16/Z)
More from this funder
Name:
National Institute for Health Research
Funding agency for:
Purshouse, K
Fairfax, B
Grant:
Intermediate Clinical Fellow (201488/Z/16/Z)
More from this funder
Name:
Department of Health
Grant:
Health Innovation Challenge Fund
More from this funder
Name:
Wellcome Trust
Grant:
Health Innovation Challenge Fund
Publisher:
Cold Spring Harbor Laboratory Press
Journal:
Cold Spring Harbor Molecular Case Studies More from this journal
Volume:
3
Issue:
3
Article number:
a001362
Publication date:
2017-03-09
Acceptance date:
2017-01-17
DOI:
EISSN:
2373-2873
ISSN:
2373-2865
Language:
English
Keywords:
Pubs id:
pubs:695509
UUID:
uuid:adae0080-1093-48f6-8846-219467c3613e
Local pid:
pubs:695509
Source identifiers:
695509
Deposit date:
2017-06-08

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