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HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.

Abstract:

The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is expression of HLA-B*57. Understanding of the mechanism for this strong effect remains incomplete. HLA-B*57 alleles and the closely related HLA-B*5801 are often grouped together because of their similar peptide-binding motifs and HIV disease outcome associations. However, we show here that the apparently small differences between HLA-B*57 alleles, termed HLA-B*57 micropoly...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.06150-11

Authors


Kloverpris, HN More by this author
Harndahl, M More by this author
van der Stok, M More by this author
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Journal:
Journal of virology
Volume:
86
Issue:
2
Pages:
919-929
Publication date:
2012-01-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:adadd0f4-ba33-4157-9ef6-afbc8bed987e
Source identifiers:
206010
Local pid:
pubs:206010

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