- Abstract:
-
Small noncoding RNAs called microRNAs (miRNAs) have emerged as post-transcriptional regulators of gene expression related to host defenses. Here, we have used Drosophila melanogaster to explore the contribution of individual or clusters of miRNAs in countering systemic Candida albicans infection. From a total of 72 tested, we identify 6 miRNA allelic mutant backgrounds that modulate the survival response to infection and the ability to control pathogen number. These mutants also exhibit dysre...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.7MB)
-
- Publisher copy:
- 10.1534/genetics.116.196584
-
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- Funding agency for:
- Atilano, ML
- Funding agency for:
- Ligoxygakis, P
- Publisher:
- Genetics Society of America Publisher's website
- Journal:
- Genetics Journal website
- Volume:
- 207
- Issue:
- 1
- Pages:
- 163-178
- Publication date:
- 2017-09-05
- Acceptance date:
- 2017-07-07
- DOI:
- EISSN:
-
1943-2631
- ISSN:
-
0016-6731
- Pubs id:
-
pubs:709566
- URN:
-
uri:adadb969-e2ef-418a-a77d-9197722d5135
- UUID:
-
uuid:adadb969-e2ef-418a-a77d-9197722d5135
- Local pid:
- pubs:709566
- Language:
- English
- Keywords:
- Copyright holder:
- © 2017 Atilano et al.
- Copyright date:
- 2017
- Notes:
- This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
MicroRNAs that contribute to coordinating the immune response in Drosophila melanogaster
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+ European Molecular Biology organization Postdoctoral Fellowship
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+ Biotechnology and Biological Sciences Research Council
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