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Journal article

MicroRNAs that contribute to coordinating the immune response in Drosophila melanogaster

Abstract:

Small noncoding RNAs called microRNAs (miRNAs) have emerged as post-transcriptional regulators of gene expression related to host defenses. Here, we have used Drosophila melanogaster to explore the contribution of individual or clusters of miRNAs in countering systemic Candida albicans infection. From a total of 72 tested, we identify 6 miRNA allelic mutant backgrounds that modulate the survival response to infection and the ability to control pathogen number. These mutants also exhibit dysre...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1534/genetics.116.196584

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Biochemistry
Oxford college:
St Cross College
Role:
Author
More from this funder
Funding agency for:
Ligoxygakis, P
Publisher:
Genetics Society of America Publisher's website
Journal:
Genetics Journal website
Volume:
207
Issue:
1
Pages:
163-178
Publication date:
2017-09-05
Acceptance date:
2017-07-07
DOI:
EISSN:
1943-2631
ISSN:
0016-6731
Pubs id:
pubs:709566
URN:
uri:adadb969-e2ef-418a-a77d-9197722d5135
UUID:
uuid:adadb969-e2ef-418a-a77d-9197722d5135
Local pid:
pubs:709566

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