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Cytomegalovirus infection in Gambian infants leads to profound CD8 T-cell differentiation.

Abstract:

Cytomegalovirus (CMV) infection is endemic in Gambian infants, with 62% infected by 3 months and 85% by 12 months of age. We studied the CD8 T-cell responses of infants to CMV following primary infection. CMV-specific CD8 T cells, identified with tetramers, showed a fully differentiated phenotype (CD28(-) CD62L(-) CD95(+) perforin(+) granzyme A(+) Bcl-2(low)). Strikingly, the overall CD8 T-cell population developed a similar phenotype following CMV infection, which persisted for at least 12 m...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00052-07

Authors


van der Sande, M More by this author
Jeffries, D More by this author
Ismaili, J More by this author
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Journal:
Journal of virology
Volume:
81
Issue:
11
Pages:
5766-5776
Publication date:
2007-06-05
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:ada3bbbd-62c2-49f0-8935-a04641555bf7
Source identifiers:
176612
Local pid:
pubs:176612

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