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The three-dimensional organization of polyribosomes in intact human cells.

Abstract:

Structural studies have provided detailed insights into different functional states of the ribosome and its interaction with factors involved in nascent peptide folding, processing, and targeting. However, how the translational machinery is organized spatially in native cellular environments is not yet well understood. Here we have mapped individual ribosomes in electron tomograms of intact human cells by template matching and determined the average structure of the ribosome in situ. Characte...

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Publication status:
Published

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Authors


Carlson, LA More by this author
Baumeister, W More by this author
Grünewald, K More by this author
Journal:
Molecular cell
Volume:
39
Issue:
4
Pages:
560-569
Publication date:
2010-08-05
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
URN:
uuid:ad9efe8e-584f-4bfa-ad35-28fb7a91c37e
Source identifiers:
73379
Local pid:
pubs:73379

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