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Journal article

Behaviour and neuropathology in mice injected with human contactin- associated protein 2 antibodies

Abstract:

Serum antibodies (Abs) that bind to the surface of neurons or glia are associated with a wide range of rare but treatable CNS diseases. In many, if not most instances, the serum levels are higher than CSF levels yet most of the reported attempts to reproduce the human disease in mice have used infusion of Abs into the mouse cerebral ventricle(s) or intrathecal space. We used the intraperitoneal (ip) route and injected purified plasma IgG from either a CASPR2-Ab positive patient (n = ten mice)...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/brain/awz119

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Institution:
University of Oxford
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Department:
RDM
Role:
Author

Contributors

Role:
Editor
Publisher:
Oxford University Press
Journal:
Brain More from this journal
Volume:
142
Issue:
7
Pages:
2000–2012
Publication date:
2019-05-11
Acceptance date:
2019-03-05
DOI:
EISSN:
1460-2156
ISSN:
0006-8950
Language:
English
Keywords:
Pubs id:
pubs:981223
UUID:
uuid:ad95c44d-45b0-4cab-9adb-ff62211e9642
Local pid:
pubs:981223
Source identifiers:
981223
Deposit date:
2019-03-10

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