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Journal article

Hydrogen bonding control in the oxidative cyclisation of 1,5-dienes

Abstract:
The regioselective dihydroxylation of a series of functionalised polyenes is described. Under acidic conditions, the osmate ester derivatives obtained from oxidation with OsO4/TMEDA undergo an intramolecular cyclisation reaction forming functionalised tetrahydrofurans with high stereoselectivity and in good yield. The generality of this method is illustrated with an application to the synthesis of a bis-tetrahydrofuran ring system. © 2001 Elsevier Science Ltd.
Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
TETRAHEDRON LETTERS More from this journal
Volume:
42
Issue:
6
Pages:
971-974
Publication date:
2001-02-05
DOI:
ISSN:
0040-4039
Language:
English
Pubs id:
pubs:37725
UUID:
uuid:ad928b01-316f-4639-8229-7a63d71400ae
Local pid:
pubs:37725
Source identifiers:
37725
Deposit date:
2012-12-19

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