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Quinolone-3-diarylethers: a new class of antimalarial drug.

Abstract:

The goal for developing new antimalarial drugs is to find a molecule that can target multiple stages of the parasite's life cycle, thus impacting prevention, treatment, and transmission of the disease. The 4(1H)-quinolone-3-diarylethers are selective potent inhibitors of the parasite's mitochondrial cytochrome bc1 complex. These compounds are highly active against the human malaria parasites Plasmodium falciparum and Plasmodium vivax. They target both the liver and blood stages of the parasit...

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Publication status:
Published
Peer review status:
Peer reviewed

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Name:
Medicines for Malaria Venture
Publisher:
American Association for the Advancement of Science
Journal:
Science translational medicine More from this journal
Volume:
5
Issue:
177
Pages:
177ra37
Publication date:
2013-03-01
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
Language:
English
Keywords:
Pubs id:
pubs:390944
UUID:
uuid:ad920ea8-4e94-462c-ac64-2030d706534c
Local pid:
pubs:390944
Source identifiers:
390944
Deposit date:
2013-11-17

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