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Journal article

Nut directs p300-dependent, genome-wide H4 hyperacetylation in male germ cells

Abstract:

Nuclear protein in testis (Nut) is a universal oncogenic driver in the highly aggressive NUT midline carcinoma, whose physiological function in male germ cells has been unclear. Here we show that expression of Nut is normally restricted to post-meiotic spermatogenic cells, where its presence triggers p300-dependent genome-wide histone H4 hyperacetylation, which is essential for the completion of histone-to-protamine exchange. Accordingly, the inactivation of Nut induces male sterility with sp...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.08.069

Authors


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Funding agency for:
Shiota, H
Grant:
PITN-GA-289880
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Funding agency for:
Shiota, H
Grant:
PITN-GA-289880
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Funding agency for:
Charbonnier, G
Grant:
FP7-PEOPLE-2011-ITN
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Funding agency for:
Picaud, S
Grant:
095751/Z/11/Z
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Funding agency for:
Filippakopoulos, P
Grant:
095751/Z/11/Z
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
24
Issue:
13
Pages:
3477-3487
Publication date:
2018-09-25
Acceptance date:
2018-08-23
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Source identifiers:
922251
Keywords:
Pubs id:
pubs:922251
UUID:
uuid:ad8decea-4ac5-48b4-8232-16a2b7b11c54
Local pid:
pubs:922251
Deposit date:
2018-10-02

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