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The effect of fentanyl, DNQX and MK-801 on dorsal horn neurones responsive to colorectal distension in the anaesthetized rat.

Abstract:

Certain dorsal horn neurones respond in a graded manner to noxious colorectal distension (CRD). Morphine inhibits these responses in the spinalized rat, but the role of excitatory amino acids in baseline visceral nociceptive transmission is less clear. This study examines the effect of the mu-opiate receptor agonist fentanyl, and the non-NMDA and NMDA antagonists DNQX and MK-801, respectively, on such responses to CRD in the sodium pentobarbitone-anaesthetized rat. Male rats were prepared for...

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Publication status:
Published

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Authors


Kozlowski, CM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Genomics Consortium
Journal:
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society
Volume:
12
Issue:
3
Pages:
239-247
Publication date:
2000-06-05
DOI:
EISSN:
1365-2982
ISSN:
1350-1925
URN:
uuid:ad7f2530-b2e9-48ab-b97a-d5c6765a4fea
Source identifiers:
31707
Local pid:
pubs:31707

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