Journal article icon

Journal article

CDP840: a novel inhibitor of PDE-4.

Abstract:

We present the in vitro characterization of a novel phosphodiesterase type 4 inhibitor, CDP840 (R-[+]-4-[2-¿3-cyclopentyloxy-4-methoxyphenyl¿-2-phenylethyl]pyridine), which has shown efficacy in a phase II allergen challenge study in asthmatics without adverse effects. CDP840 potently inhibits PDE-4 isoenzymes (IC50 2-30 nM) without any effect on PDE-1, 2, 3, 5, and 7 (IC50 > 100 microM). It exhibited no significant selectivity in inhibiting human recombinant isoenzymes PDE-4A, B, C or D a...

Expand abstract

Actions


Access Document


Publisher copy:
10.1007/bf02737831

Authors


Journal:
Cell biochemistry and biophysics More from this journal
Volume:
29
Issue:
1-2
Pages:
113-132
Publication date:
1998-01-01
DOI:
EISSN:
1559-0283
ISSN:
1085-9195
Language:
English
Keywords:
Pubs id:
pubs:171621
UUID:
uuid:ad7c0335-9008-4aec-b5af-70ba98064feb
Local pid:
pubs:171621
Source identifiers:
171621
Deposit date:
2013-02-20

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP