Journal article icon

Journal article

The Goldilocks window of personalized chemotherapy: Getting the immune response just right

Abstract:

The immune system is a robust and often untapped accomplice of many standard cancer therapies. A majority of tumors exist in a state of immune tolerance where the patient's immune system has become insensitive to the cancer cells. Due to its lymphodepleting effects, chemotherapy has the potential to break this tolerance. In order to investigate this, we created a mathematical modeling framework of tumor-immune dynamics. Our results suggest that optimal chemotherapy scheduling must balance two...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1158/0008-5472.CAN-18-3712

Authors


More by this author
Institution:
University of Oxford
Department:
Zoology
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Zoology
Oxford college:
St Peter's College
Role:
Author
ORCID:
0000-0003-0250-0423
Expand authors...
Publisher:
American Association for Cancer Research Publisher's website
Journal:
Cancer Research Journal website
Volume:
79
Issue:
20
Pages:
S302-S315
Publication date:
2019-08-06
Acceptance date:
2019-07-26
DOI:
EISSN:
1538-7445
ISSN:
0008-5472
Source identifiers:
1036228
Language:
English
Keywords:
Pubs id:
pubs:1036228
UUID:
uuid:ad7b16d0-1f8d-4185-a9b8-6ba68985d8be
Local pid:
pubs:1036228
Deposit date:
2019-07-30

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP