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Cell-permeable lanthanide-platinum(IV) anti-cancer prodrugs

Abstract:

Platinum compounds are a vital part of our anti-cancer arsenal, and determining the location and speciation of platinum compounds is crucial. We have synthesised a lanthanide complex bearing a salicylic group (Ln = Gd, Eu) which demonstrates excellent cellular accumulation and minimal cytotoxicity. Derivatisation enabled access to bimetallic lanthanide–platinum(II) and lanthanide–platinum(IV) complexes. Luminescence from the europium–platinum(IV) system was quenched, and reduction to platinum...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.1039/d1dt01688a

Authors


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Role:
Author
ORCID:
0000-0002-8072-5911
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Institution:
University of Oxford
Division:
MPLS
Department:
Earth Sciences
Role:
Author
ORCID:
0000-0002-1601-8470
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Role:
Author
ORCID:
0000-0001-8258-860X
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Cancer Research UK More from this funder
Publisher:
Royal Society of Chemistry Publisher's website
Journal:
Dalton Transactions Journal website
Volume:
50
Issue:
25
Pages:
8761-8767
Publication date:
2021-05-28
Acceptance date:
2021-05-28
DOI:
EISSN:
1477-9234
ISSN:
1477-9226
Pmid:
34080595
Language:
English
Keywords:
Pubs id:
1180661
Local pid:
pubs:1180661
Deposit date:
2021-11-12

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