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Comparative analysis of gnathostome Otx gene expression patterns in the developing eye: implications for the functional evolution of the multigene family.

Abstract:

We have performed a detailed analysis of the expression pattern of the three gnathostome Otx classes in order to gain new insights into their functional evolution. Expression patterns were examined in the developing eye of a chondrichthyan, the dogfish, and an amniote, the chick, and compared with the capacity of paralogous proteins to induce a pigmented phenotype in cultured retina cells in cooperation with the bHLH-leucine zipper protein Mitf. This analysis indicates that each Otx class is ...

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Publisher copy:
10.1016/j.ydbio.2004.11.019

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Journal:
Developmental biology
Volume:
278
Issue:
2
Pages:
560-575
Publication date:
2005-02-05
DOI:
EISSN:
1095-564X
ISSN:
0012-1606
URN:
uuid:ad6ec947-905c-4348-973a-b9288ac10e2e
Source identifiers:
265252
Local pid:
pubs:265252

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