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Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual Plasmodium falciparum lysates: evidence for association with protection for IgG1 and disease for IgG2.

Abstract:

There is longstanding evidence for a role of immunoglobulin (Ig)G in protection against malarial disease and infection. IgG1 and IgG3 have been shown to be particularly efficient at associating with monocytes in potentially protective mechanisms (i.e. antibody-dependent cellular inhibition, opsonization and phagocytosis). Conversely, there is some evidence that IgG2 (and possibly IgG4) antibodies may be antagonistic to this protection. The protective effect of IgG subclass antibody activity p...

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Publication status:
Published

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Authors


Ndungu, FM More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
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Journal:
Parasite immunology
Volume:
24
Issue:
2
Pages:
77-82
Publication date:
2002-02-05
DOI:
EISSN:
1365-3024
ISSN:
0141-9838
URN:
uuid:ad6b482d-b06b-4970-ab2d-f922602d434f
Source identifiers:
38186
Local pid:
pubs:38186

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