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Ordinal vs dichotomous analyses of modified Rankin Scale, 5-year outcome, and cost of stroke

Abstract:

Objective: To compare how 3 common representations (ordinal vs dichotomized as 0–1/2–6 or 0–2/3–6) of the modified Rankin Scale (mRS)—a commonly used trial outcome measure—relate to long-term outcomes, and quantify trial ineligibility rates based on premorbid mRS.

Methods: In consecutive patients with ischemic stroke in a population-based, prospective, cohort study (Oxford Vascular Study; 2002–2014), we related 3-month mRS to 1-year and 5-year disability and death (logistic regress...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1212/wnl.0000000000006554

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Nuffield Department of Population Health
Sub department:
Population Health
Oxford college:
St Hilda's College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
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Funding agency for:
Ganesh, A
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Funding agency for:
Rothwell, P
National Institute for Health Research More from this funder
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Publisher:
American Academy of Neurology Publisher's website
Journal:
Neurology Journal website
Volume:
91
Issue:
21
Pages:
e1951-e1960
Publication date:
2018-10-19
Acceptance date:
2018-08-08
DOI:
EISSN:
1526-632X
ISSN:
0028-3878
Pmid:
30341155
Source identifiers:
934781
Language:
English
Keywords:
Pubs id:
pubs:934781
UUID:
uuid:ad66e55e-df4b-4815-9ca9-56a52a790f64
Local pid:
pubs:934781
Deposit date:
2018-11-02

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