Journal article
Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.
- Abstract:
-
DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-derived epitope were elicited in rhesus macaques. These vaccine-induced CTLs were capable of killing SIV-infected cells in vitro. Fluorescence-activated cell sorter analysis using soluble tetrameric ma...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of virology
- Volume:
- 73
- Issue:
- 9
- Pages:
- 7524-7532
- Publication date:
- 1999-09-05
- EISSN:
-
1098-5514
- ISSN:
-
0022-538X
- URN:
-
uuid:ad578702-be1a-44de-ba95-90ab318ac58d
- Source identifiers:
-
31534
- Local pid:
- pubs:31534
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- Copyright date:
- 1999
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