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Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.

Abstract:

DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-derived epitope were elicited in rhesus macaques. These vaccine-induced CTLs were capable of killing SIV-infected cells in vitro. Fluorescence-activated cell sorter analysis using soluble tetrameric ma...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Samuel, RV More by this author
Blanchard, TJ More by this author
Neumann, VC More by this author
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Journal:
Journal of virology
Volume:
73
Issue:
9
Pages:
7524-7532
Publication date:
1999-09-05
EISSN:
1098-5514
ISSN:
0022-538X
URN:
uuid:ad578702-be1a-44de-ba95-90ab318ac58d
Source identifiers:
31534
Local pid:
pubs:31534

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