Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.

Hanke, T; Samuel, RV; Blanchard, TJ; Neumann, VC; Allen, TM; Boyson, JE; Sharpe, SA; Cook, N; Smith, GL; Watkins, DI; Cranage, MP; Mcmichael, AJ

Abstract:

DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-derived epitope were elicited in rhesus macaques. These vaccine-induced CTLs were capable of killing SIV-infected cells in vitro. Fluorescence-activated cell sorter analysis using soluble tetrameric ma...

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Published

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APA Style

Hanke, T., Samuel, R. V., Blanchard, T. J., Neumann, V. C., Allen, T. M., Boyson, J. E., Sharpe, S. A., Cook, N., Smith, G. L., Watkins, D. I., Cranage, M. P., & Mcmichael, A. J. (1999). Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen. Journal of Virology, 73(9), 7524–7532.

MLA Style

Hanke, T., et al. “Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen.” Journal of Virology, vol. 73, no. 9, Journal of virology, 1999, pp. 7524–32.

Chicago Style

Hanke, T, RV Samuel, TJ Blanchard, VC Neumann, TM Allen, JE Boyson, SA Sharpe, et al. 1999. “Effective Induction of Simian Immunodeficiency Virus-Specific Cytotoxic T Lymphocytes in Macaques by Using a Multiepitope Gene and DNA Prime-Modified Vaccinia Virus Ankara Boost Vaccination Regimen.” Journal of Virology 73 (9): 7524–32.
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Authors

+ Hanke, T More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, Clinical Medicine, Jenner Institute

Samuel, RV More by this author

Blanchard, TJ More by this author

Neumann, VC More by this author

Allen, TM More by this author

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Bibliographic Details

Journal:: Journal of virology
Volume:: 73
Issue:: 9
Pages:: 7524-7532
Publication date:: 1999-09-05
EISSN:: 1098-5514
ISSN:: 0022-538X
URN:: uuid:ad578702-be1a-44de-ba95-90ab318ac58d
Source identifiers:: 31534
Local pid:: pubs:31534

Item Description

Language:: English
Keywords:: Animals

Vaccines, DNA

T-Lymphocytes, Cytotoxic

Humans

Epitopes, T-Lymphocyte

Vaccinia virus

Vaccination

Viral Vaccines

Genes, Viral

CD8-Positive T-Lymphocytes

Macaca mulatta

Mice

DNA, Viral

Chick Embryo

Simian immunodeficiency virus

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