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Oxidative phosphorylation as an emerging target in cancer therapy

Abstract:

Cancer cells have upregulated glycolysis compared to normal cells, which has led many to the assumption that oxidative phosphorylation (OXPHOS) is downregulated in all cancers.  However, recent studies have shown that OXPHOS can be also upregulated in certain cancers, including leukemias, lymphomas, pancreatic ductal adenocarcinoma, high OXPHOS subtype melanoma and endometrial carcinoma, and that this can occur even in the face of active glycolysis.  OXPHOS inhibitors could therefore be used ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Sub department:
CRUK/MRC Ox Inst for Radiation Oncology
Role:
Author
ORCID:
0000-0003-3072-909X
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Name:
Medical Research Council
Grant:
McKenna MC_PC_12004
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Name:
Cancer Research UK
Grant:
Higgins C34326/A13092, McKenna C5255/A23755
Publisher:
American Association for Cancer Research
Journal:
Clinical Cancer Research More from this journal
Volume:
24
Issue:
11
Pages:
2482-2490
Publication date:
2018-02-02
Acceptance date:
2018-01-30
DOI:
EISSN:
1557-3265
ISSN:
1078-0432
Pmid:
29420223
Language:
English
Keywords:
Pubs id:
pubs:823469
UUID:
uuid:ad53fe47-0658-4591-b237-33264b482f86
Local pid:
pubs:823469
Source identifiers:
823469
Deposit date:
2018-02-28

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