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Journal article

Micelles protect membrane complexes from solution to vacuum.

Abstract:

The ability to maintain interactions between soluble protein subunits in the gas phase of a mass spectrometer gives critical insight into the stoichiometry and interaction networks of protein complexes. Conversely, for membrane protein complexes in micelles, the transition into the gas phase usually leads to the disruption of interactions, particularly between cytoplasmic and membrane subunits, and a mass spectrum dominated by large aggregates of detergent molecules. We show that by applying ...

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Publication status:
Published

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Publisher copy:
10.1126/science.1159292

Authors


Barrera, NP More by this author
Di Bartolo, N More by this author
Robinson, CV More by this author
Journal:
Science (New York, N.Y.)
Volume:
321
Issue:
5886
Pages:
243-246
Publication date:
2008-07-05
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
URN:
uuid:ad45b76c-1b79-4d10-9c48-658ed1d4aff8
Source identifiers:
59313
Local pid:
pubs:59313

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