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Transient limb ischemia induces remote ischemic preconditioning in vivo.

Abstract:

BACKGROUND: Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning. We tested the hypothesis that limb ischemia induces remote preconditioning, reduces endothelial IR injury in humans, and reduces experimental myocardial infarct size. METHODS AND RESULTS: Endothelial IR injury of the human forearm was induced by 20 minutes of upper limb ischemi...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Cardiovascular Medicine
Mortensen, UM More by this author
Kristiansen, SB More by this author
Schmidt, MR More by this author
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Journal:
Circulation
Volume:
106
Issue:
23
Pages:
2881-2883
Publication date:
2002-12-05
DOI:
EISSN:
1524-4539
ISSN:
0009-7322
URN:
uuid:ad36849e-6d6e-4917-8a0e-1cbb3fe7b27e
Source identifiers:
105004
Local pid:
pubs:105004

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