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Journal article

Shared changes in gene expression in frontal cortex of four genetically modified mouse models of depression.

Abstract:

This study aimed to identify whether genetic manipulation of four systems implicated in the pathogenesis of depression converge on shared molecular processes underpinning depression-like behaviour in mice. Altered 5HT function was modelled using the 5-HT transporter knock out mouse, impaired glucocorticoid receptor (GR) function using an antisense-induced knock down mouse, disrupted glutamate function using a heterozygous KO of the vesicular glutamate transporter 1 gene, and impaired cannabin...

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Publication status:
Published

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Journal:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology More from this journal
Volume:
21
Issue:
1
Pages:
3-10
Publication date:
2011-01-01
DOI:
EISSN:
1873-7862
ISSN:
0924-977X

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