TBX2 expression is regulated by PAX3 in the melanocyte lineage.

Journal article

The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is involved in the survival of melanoma cells and is overexpressed in some melanoma specimens. The identification of TBX2 as a target for PAX3 provides a key insight into how PAX3 may contribute to melanoma evolution and may provide opportunities for prosenescence therapeutic intervention aimed at disrupting the ability of PAX3 to regulate TBX2.

Authors: Liu, F; Cao, J; Lv, J; Dong, L; Pier, E

• Publication status: Published
• Journal: Pigment cell and melanoma research
• Volume: 26
• Issue: 1
• Pages: 67-77
• Publication date: 2013-01-01
• DOI: 10.1111/pcmr.12029
• EISSN: 1755-148X
• ISSN: 1755-1471
• Language: English
• Keywords: Melanoma; Oligonucleotide Array Sequence Analysis; Gene Expression Regulation; Humans; Mice; Cell Proliferation; Promoter Regions, Genetic; Animals; Cell Survival; Protein Binding; T-Box Domain Proteins; Paired Box Transcription Factors; Chromatin Immunoprecipitation; Cell Lineage; Gene Expression Regulation, Neoplastic; Up-Regulation; Melanocytes