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Journal article

TBX2 expression is regulated by PAX3 in the melanocyte lineage.

Abstract:

The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is i...

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Publication status:
Published

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Publisher copy:
10.1111/pcmr.12029

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Journal:
Pigment cell and melanoma research
Volume:
26
Issue:
1
Pages:
67-77
Publication date:
2013-01-05
DOI:
EISSN:
1755-148X
ISSN:
1755-1471
URN:
uuid:ad2eff46-c506-4ec0-bdbe-4a4d970f6dcf
Source identifiers:
353956
Local pid:
pubs:353956

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