- Abstract:
-
The paired box homeotic gene 3 (PAX3) is a crucial regulator for the maintenance of melanocytic progenitor cells and has a poorly defined role in melanoma. To understand how PAX3 affects melanocyte and melanoma proliferation, we identified potential PAX3 downstream targets through gene expression profiling. Here, we identify T-box 2 (TBX2), a key developmental regulator of cell identity and an antisenescence factor in melanoma, as a directly regulated PAX3 target. We also found that TBX2 is i...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1111/pcmr.12029
-
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- Journal:
- Pigment cell and melanoma research
- Volume:
- 26
- Issue:
- 1
- Pages:
- 67-77
- Publication date:
- 2013-01-05
- DOI:
- EISSN:
-
1755-148X
- ISSN:
-
1755-1471
- URN:
-
uuid:ad2eff46-c506-4ec0-bdbe-4a4d970f6dcf
- Source identifiers:
-
353956
- Local pid:
- pubs:353956
- Language:
- English
- Keywords:
- Copyright date:
- 2013
Journal article
TBX2 expression is regulated by PAX3 in the melanocyte lineage.
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