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Differential impact of nevirapine on artemether-lumefantrine pharmacokinetics in individuals stratified by CYP2B6 c.516G>T genotypes

Abstract:

There is an increased recognition of the need to identify and quantify the impact of genetic polymorphisms on drug-drug interactions. This study investigated the pharmacogenetics of the pharmacokinetic drug-drug interaction between nevirapine and artemether-lumefantrine in HIV-positive and HIV-negative adult Nigerian subjects. Thirty each of HIV-infected patients on nevirapine-based antiretroviral therapy and HIV-negative volunteers without clinical malaria, but with predetermined CYP2B6 c.51...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-1470-7483
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Role:
Author
ORCID:
0000-0002-6588-5749
Publisher:
American Society for Microbiology
Journal:
Antimicrobial Agents and Chemotherapy More from this journal
Volume:
64
Issue:
3
Article number:
e00947-19
Place of publication:
United States
Publication date:
2020-02-21
Acceptance date:
2019-12-02
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pmid:
31871092
Language:
English
Keywords:
Pubs id:
1080061
Local pid:
pubs:1080061
Deposit date:
2020-07-21

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