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CT60 and +49 polymorphisms of CTLA 4 are associated with ANCA-positive small vessel vasculitis.

Abstract:

OBJECTIVE: To investigate whether single nucleotide polymorphisms (SNPs) within cytotoxic T-lymphocyte antigen-4 (CTLA-4) are associated with ANCA-associated small vessel vasculitis (SVV). METHODS: The CTLA-4 CT60 (exon 4), +49 (exon 1) and -318 (promoter region) genotypes were determined by PCR and restriction fragment length polymorphism (RFLP) in 222 white Caucasians of UK origin with SVV and 670 ethnically matched controls. RESULTS: The CTLA-4 exon 1 (+49) and 4 (CT60) polymorphisms are ...

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Publisher copy:
10.1093/rheumatology/kep280

Authors


Heward, JM More by this author
Williams, JM More by this author
Chavele, KM More by this author
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Journal:
Rheumatology (Oxford, England)
Volume:
48
Issue:
12
Pages:
1502-1505
Publication date:
2009-12-05
DOI:
EISSN:
1462-0332
ISSN:
1462-0324
URN:
uuid:ad28fdb4-e6ef-4af5-ba17-ead294b3a988
Source identifiers:
176429
Local pid:
pubs:176429

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