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Tropomyosin-related kinase A (TrkA) inhibition for the treatment of painful knee osteoarthritis: results from a randomized controlled phase 2a trial

Abstract:

Objective To investigate the TrkA inhibitor, ASP7962, for treatment of painful knee osteoarthritis.

Design Phase 2a, double-blind, placebo- and naproxen-controlled, double-dummy, parallel-group study. Adults with knee osteoarthritis were randomized (2:2:1) to ASP7962 (100 mg), placebo, or naproxen (500 mg) twice daily (BID) for 4 weeks. Primary endpoint: change from baseline to Week 4 in Western Ontario and McMaster Universities Arthritis Index (WO...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Kennedy Institute for Rheumatology
Role:
Author
Publisher:
Elsevier
Journal:
Osteoarthritis and Cartilage More from this journal
Volume:
27
Issue:
11
Pages:
1590–1598
Publication date:
2019-07-26
Acceptance date:
2019-05-29
DOI:
EISSN:
1522-9653
ISSN:
1063-4584
Language:
English
Keywords:
Pubs id:
pubs:1024735
UUID:
uuid:ad26e7c0-bec8-4816-b4f7-9de9dc5caee6
Local pid:
pubs:1024735
Source identifiers:
1024735
Deposit date:
2019-06-30

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