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Resolving postoperative neuroinflammation and cognitive decline.

Abstract:

OBJECTIVE: Cognitive decline accompanies acute illness and surgery, especially in the elderly. Surgery engages the innate immune system that launches a systemic inflammatory response that, if unchecked, can cause multiple organ dysfunction. We sought to understand the mechanisms whereby the brain is targeted by the inflammatory response and how this can be resolved. METHODS: C57BL/6J, Ccr2(RFP/+)Cx3cr1(GFP/+), Ikk(F/F) mice and LysM-Cre/Ikk(F/F) mice underwent stabilized tibial fracture oper...

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Publication status:
Published

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Publisher copy:
10.1002/ana.22664

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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Annals of neurology More from this journal
Volume:
70
Issue:
6
Pages:
986-995
Publication date:
2011-12-01
DOI:
EISSN:
1531-8249
ISSN:
0364-5134

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