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IL-1RI deficiency ameliorates early experimental renal interstitial fibrosis.

Abstract:

BACKGROUND: IL-1beta has the potential to promote progressive renal disease by effects on macrophage recruitment and activation or by effects mediated through tubular cell transforming growth factor (TGF)-beta production, previously demonstrated in vitro. METHODS: The in vivo roles of endogenous IL-1beta and its type I receptor (IL-1RI) in renal fibrosis were studied using wild-type C57BL/6 mice, IL-1beta(-/-) and IL-1RI(-/-) mice with unilateral ureteric obstruction. RESULTS: After 7 days, ...

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Publication status:
Published

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Publisher copy:
10.1093/ndt/gfp214

Authors


O'Sullivan, KM More by this author
Kuligowski, MP More by this author
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Journal:
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
Volume:
24
Issue:
10
Pages:
3024-3032
Publication date:
2009-10-05
DOI:
EISSN:
1460-2385
ISSN:
0931-0509
URN:
uuid:ad1ee3ef-df18-4f50-91f6-1c4fce6fe7c7
Source identifiers:
106970
Local pid:
pubs:106970

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