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Journal article

The impact of variation in the number of CD8(+) T-cell precursors on the outcome of virus infection.

Abstract:

We investigated the role of varying the initial number of naive antiviral CTL precursors on the dynamics of LCMV-DOCILE infection. C57BL/6 mice, exhibiting LCMV-specific CTLp frequencies of about 50, are protected against virus persistence over a range of infectious doses up to 10(4) pfu. With 10-fold higher doses, a 100-fold increase in CTLp is required to restore virus control. With doses above 10(6) pfu, elevation of the initial CTLp number leads only to lethal immunopathology. Similarly, ...

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Publication status:
Published

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Publisher copy:
10.1006/cimm.1998.1344

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
Journal:
Cellular immunology More from this journal
Volume:
189
Issue:
1
Pages:
67-73
Publication date:
1998-10-01
DOI:
EISSN:
1090-2163
ISSN:
0008-8749
Language:
English
Keywords:
Pubs id:
pubs:15481
UUID:
uuid:ad1e56f1-b4e2-4331-bfe5-16911d32e35c
Local pid:
pubs:15481
Source identifiers:
15481
Deposit date:
2012-12-19

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