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Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.

Abstract:

The nucleotide-binding domain, leucine-rich repeat containing family caspase recruitment domain containing 4 (NLRC4) inflammasome can be activated by pathogenic bacteria via products translocated through the microbial type III secretion apparatus (T3SS). Recent work has shown that activation of the NLRP3 inflammasome is downregulated by autophagy, but the influence of autophagy on NLRC4 activation is unclear. We set out to determine how autophagy might influence this process, using the bacter...

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Publication status:
Published
Peer review status:
Peer Reviewed
Version:
Publishers PDF

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Publisher copy:
10.4161/15548627.2014.981915

Authors


Hopkins, L More by this author
Ritchie, ND More by this author
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Ministry of Higher Education and Scientific Research More from this funder
Journal:
Autophagy
Volume:
11
Issue:
1
Pages:
166-182
Publication date:
2015-01-05
DOI:
EISSN:
1554-8635
ISSN:
1554-8627
URN:
uuid:ad0b506f-1a4e-4e0a-8cf7-c6fc1abf9d44
Source identifiers:
509578
Local pid:
pubs:509578

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