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The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure.

Abstract:

Activation of p53 target genes for tumor suppression depends on the stress-specific regulation of transcriptional coactivator complexes. Strap (stress-responsive activator of p300) is activated upon DNA damage by ataxia telangiectasia mutated (ATM) and Chk2 kinases and is a key regulator of the p53 response. In addition to antagonizing Mdm2, Strap facilitates the recruitment of p53 coactivators, including JMY and p300. Strap is a predicted TPR-repeat protein, but shows only limited sequence i...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.1113731109

Authors


Sharpe, TD More by this author
Coutts, AS More by this author
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
109
Issue:
10
Pages:
3778-3783
Publication date:
2012-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:ad09a621-f2ea-4e83-b539-8c8427d1611a
Source identifiers:
313152
Local pid:
pubs:313152

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