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The thyroglobulin gene: The third locus for autoimmune thyroid disease or a false dawn?

Abstract:

Genetic studies have identified the HLA and CTLA4 regions as susceptibility loci for the development of common autoimmune thyroid diseases (AITDs), including Graves' disease and autoimmune hypothyroidism. Despite numerous studies, the identification of a third locus has remained elusive. Genetic-linkage studies have implicated chromosome 8q24 as a susceptibility locus for AITD. The gene encoding thyroglobulin (Tg), which encodes a major thyroid autoantigen, maps to this region, and a recent s...

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Journal:
Trends in Molecular Medicine
Volume:
10
Issue:
7
Pages:
302-305
Publication date:
2004-07-01
DOI:
ISSN:
1471-4914
URN:
uuid:ad090aef-b19a-4dbd-916b-f439557cb276
Source identifiers:
176343
Local pid:
pubs:176343
Language:
English

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