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Bifunctional nanoarrays for probing the immune response at the single-molecule level.

Abstract:

Bifunctional nanoarrays were created to simulate the immunological synapse and probe the T-cell immune response at the single-molecule level. Sub-5 nm AuPd nanodot arrays were fabricated using both e-beam and nanoimprint lithography. The nanoarrays were then functionalized by two costimulatory molecules: antibody UCHT1 Fab, which binds to the T-cell receptor (TCR) and activates the immune response, bound to metallic nanodots; and intercellular adhesion molecule-1, which enhances cell adhesion...

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Publisher copy:
10.1116/1.4823764

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Journal of vacuum science and technology. B, Nanotechnology and microelectronics : materials, processing, measurement, and phenomena : JVST B
Volume:
31
Issue:
6
Pages:
6F902
Publication date:
2013-11-05
DOI:
EISSN:
2166-2754
ISSN:
2166-2746
URN:
uuid:ad045997-7f72-46a9-83cc-6dcbeeec49ef
Source identifiers:
453900
Local pid:
pubs:453900
Language:
English

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