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Human leukocyte antigen variants B*44 and B*57 are consistently favorable during two distinct phases of primary HIV-1 infection in sub-Saharan Africans with several viral subtypes.

Abstract:

As part of an ongoing study of early human immunodeficiency virus type 1 (HIV-1) infection in sub-Saharan African countries, we have identified 134 seroconverters (SCs) with distinct acute-phase (peak) and early chronic-phase (set-point) viremias. SCs with class I human leukocyte antigen (HLA) variants B*44 and B*57 had much lower peak viral loads (VLs) than SCs without these variants (adjusted linear regression beta values of -1.08 ± 0.26 log(10) [mean ± standard error] and -0.83 ± 0.27 log(...

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Publication status:
Published

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Publisher copy:
10.1128/jvi.00439-11

Authors


Journal:
Journal of virology More from this journal
Volume:
85
Issue:
17
Pages:
8894-8902
Publication date:
2011-09-01
DOI:
EISSN:
1098-5514
ISSN:
0022-538X
Language:
English
Keywords:
Pubs id:
pubs:179640
UUID:
uuid:ad042421-8765-42ee-a775-e61cd3c43cc6
Local pid:
pubs:179640
Source identifiers:
179640
Deposit date:
2012-12-19

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