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Crystal structure of an octameric RuvA-Holliday junction complex.

Abstract:

Holliday junctions occur as intermediates in homologous recombination and DNA repair. In bacteria, resolution of Holliday junctions is accomplished by the RuvABC system, consisting of a junction-specific helicase complex RuvAB, which promotes branch migration, and a junction-specific endonuclease RuvC, which nicks two strands. The crystal structure of a complex between the RuvA protein of M. leprae and a synthetic four-way junction has now been determined. Rather than binding on the open surf...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Molecular cell More from this journal
Volume:
2
Issue:
3
Pages:
361-372
Publication date:
1998-09-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765

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