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Journal article

Reduction of cPLA2alpha overexpression: an efficient anti-inflammatory therapy for collagen-induced arthritis.

Abstract:

Cytosolic phospholipase A2alpha (cPLA2) plays an important role in the development of several inflammatory diseases. The aim of the present study is to determine whether inhibition of cPLA2 expression, using specific antisense oligonucleotides against cPLA2 (antisense), is efficient in reducing inflammation after its development. Two mouse models of inflammation were included in the study: thioglicolate peritonitis and collagen-induced arthritis (CIA). The antisense was found to be specific a...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200838545

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Journal:
European journal of immunology
Volume:
38
Issue:
10
Pages:
2905-2915
Publication date:
2008-10-01
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
Source identifiers:
223910
Language:
English
Keywords:
Pubs id:
pubs:223910
UUID:
uuid:acf19bf1-158d-4d06-9f78-8fdd1e96696f
Local pid:
pubs:223910
Deposit date:
2012-12-19

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