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Biochemistry: Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis

Abstract:

Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family ...

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Publisher copy:
10.1126/science.1120615

Authors


Journal:
Science More from this journal
Volume:
310
Issue:
5755
Pages:
1821-1824
Publication date:
2005-12-16
DOI:
EISSN:
1095-9203
ISSN:
0036-8075
Language:
English
Pubs id:
pubs:365419
UUID:
uuid:ace9a1d7-cb87-49b7-aa8b-4a05d2585fc6
Local pid:
pubs:365419
Source identifiers:
365419
Deposit date:
2013-11-16

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