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Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

Abstract:

Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease. Previous work has established that differentiation protocols can produce cortical neurons, but little has been done to characterize these at cellular resolution. In particular, it is unclear to what extent in vitro two-dimensional, relatively disordered culture conditions recapitulate the development of in vivo cortical layer identity. S...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddv637

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Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD
Role:
Author
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Funding agency for:
Handel, AE
European Union More from this funder
European Federation of Pharmaceutical Industries and Associations More from this funder
Oxford Martin School More from this funder
Wellcome Trust More from this funder
Publisher:
Oxford University Press Publisher's website
Journal:
Human molecular genetics Journal website
Volume:
25
Issue:
5
Pages:
989-1000
Publication date:
2016-03-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:ace4ba4d-6850-4eec-97c3-66d5805208f7
Source identifiers:
587158
Local pid:
pubs:587158
Language:
English

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