Journal article
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
- Abstract:
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Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease. Previous work has established that differentiation protocols can produce cortical neurons, but little has been done to characterize these at cellular resolution. In particular, it is unclear to what extent in vitro two-dimensional, relatively disordered culture conditions recapitulate the development of in vivo cortical layer identity. S...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.1MB)
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- Publisher copy:
- 10.1093/hmg/ddv637
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Authors
Funding
European Federation of Pharmaceutical Industries and Associations
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Oxford Martin
School
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European Union
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Wellcome Trust
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human molecular genetics Journal website
- Volume:
- 25
- Issue:
- 5
- Pages:
- 989-1000
- Publication date:
- 2016-03-01
- Acceptance date:
- 2015-12-31
- DOI:
- EISSN:
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1460-2083
- ISSN:
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0964-6906
- Source identifiers:
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587158
Item Description
- Language:
- English
- Pubs id:
-
pubs:587158
- UUID:
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uuid:ace4ba4d-6850-4eec-97c3-66d5805208f7
- Local pid:
- pubs:587158
- Deposit date:
- 2016-03-06
Terms of use
- Copyright holder:
- Handel et al
- Copyright date:
- 2016
- Notes:
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© The Author 2016. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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