- Abstract:
-
Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease. Previous work has established that differentiation protocols can produce cortical neurons, but little has been done to characterize these at cellular resolution. In particular, it is unclear to what extent in vitro two-dimensional, relatively disordered culture conditions recapitulate the development of in vivo cortical layer identity. S...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Publisher's version
- Files:
-
-
(pdf, 1.1MB)
-
- Publisher copy:
- 10.1093/hmg/ddv637
-
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- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Human molecular genetics Journal website
- Volume:
- 25
- Issue:
- 5
- Pages:
- 989-1000
- Publication date:
- 2016-03-05
- DOI:
- EISSN:
-
1460-2083
- ISSN:
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0964-6906
- URN:
-
uuid:ace4ba4d-6850-4eec-97c3-66d5805208f7
- Source identifiers:
-
587158
- Local pid:
- pubs:587158
- Language:
- English
- Copyright holder:
- Handel et al.
- Copyright date:
- 2016
- Notes:
-
© The Author 2016. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal article
Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics
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European Union
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