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Assessing similarity to primary tissue and cortical layer identity in induced pluripotent stem cell-derived cortical neurons through single-cell transcriptomics

Abstract:

Induced pluripotent stem cell (iPSC)-derived cortical neurons potentially present a powerful new model to understand corticogenesis and neurological disease. Previous work has established that differentiation protocols can produce cortical neurons, but little has been done to characterize these at cellular resolution. In particular, it is unclear to what extent in vitro two-dimensional, relatively disordered culture conditions recapitulate the development of in vivo cortical layer identity. S...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddv637

Authors


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Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Handel, A
Grant:
100643/Z/12/Z
More from this funder
Name:
European Federation of Pharmaceutical Industries and Associations
Publisher:
Oxford University Press
Journal:
Human molecular genetics More from this journal
Volume:
25
Issue:
5
Pages:
989-1000
Publication date:
2016-03-01
Acceptance date:
2015-12-31
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Pubs id:
pubs:587158
UUID:
uuid:ace4ba4d-6850-4eec-97c3-66d5805208f7
Local pid:
pubs:587158
Source identifiers:
587158
Deposit date:
2016-03-06

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